CellMosaic has designed this kit for antibody (IgG) labeling of SN38, the active metabolite of irinotecan, for early stage screening of your antibody.

Irinotecan is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. SN38 is 1000-times more active than irinotecan, but is not generally used as a drug due to its poor water solubility. If it is conjugated to a protein or antibody, the protein/antibody can transport SN38 to the active site. This kit includes a chemically modified SN38 with a releasable spacer, which can be coupled directly to the antibody in a single step. The product is purified to remove any unreacted SN38. 

This kit provides materials to label one antibody. Scale of the reaction: 3 mg.

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Drug Information

• Name: SN38 (7-ethyl-10-hydroxycamptothecin)
• CAS number: 86639-52-3
• Mechanism of action:  Inhibition of topoisomerase I leads to inhibition of both DNA replication and transcription.
• Medical usage: Pro-drug Irinotecan (brand name: Camptosar) is used for treatment of colon and small cell lung cancer

Key Features of this PerKit™

• Offers a simple and easy way to label IgG with SN38
• Releasable ester bond
• Single conjugation step, fast and easy preparation: 4 h preparation and <30 minutes hands-on time
• All reagents and supplies included for preparation and purification
• Over 90% pure conjugated products by SEC
• Options to choose tailored services at CellMosaic after conjugation

After conjugation: you can choose to send your sample to CellMosaic for HPLC analysis and calculation of the DOL.