CellMosaic has designed this kit for antibody (IgG) labeling of doxorubicin for early stage screening of your antibody.

Doxorubicin is an anticancer drug on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The kit includes a chemically modified doxorubicin with a spacer that can be coupled directly to the antibody in a single step. The product is purified to remove any unreacted doxorubicin. 

This kit provides materials to label one antibody. Scale of the reaction: 3 mg.

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Drug Information

• Name: Doxorubicin (trade name: Adriamycin)
• CAS number: 23214-92-8
• Mechanism of action: Intercalation of DNA and inhibition of macromolecular biosynthesis.
• Medical usage: Breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia.
• ADC usage: Doxorubicin has been linked to an antibody and found to be effective in treating lung cancer (Ref. Trail, PA et al. 1993, Science, 261, 212-215) 

Key Features of this PerKit™

• Offers a simple and easy way to label IgG with Doxorubicin with minimum expose to the chemotherapeutic drug
• Stable chemical bond
• Pre-weighed and single conjugation step, fast and easy preparation: 4 h preparation and <30 minutes hands-on time
• All reagents and supplies included for preparation and purification 
• Over 90% pure conjugated products by SEC
• Options to choose tailored services at CellMosaic after conjugation

After conjugation: you can choose to send your sample to CellMosaic for HPLC analysis and determination of the DOL.