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PDC Kits
PDC Personalized Conjugation Kits (PerKits™)
CellMosaic is now providing PerKits™ to help our life science clients quickly evaluate proteins with direct conjugation of a range of key payloads (chemotherapeutic drugs and toxins) and traditional linker chemistry. Kits are available in many configurations with a variety of conjugation strategies. CellMosaic protein-drug conjugate (PDC) PerKits™ are available to prepare conjugates through surface amines. Some PDC kits apply to a general payload with certain functional groups, such as carboxylic acid and amine. Some PDC kits supply the selected, standard linkage molecules conjugated to a selected payload, ready with the appropriate reactive modifications to directly attach the payload and linker to your specific antibody of interest. The kits are complete with all reagents and procedures for attaching the selected payload directly to your antibody and purifying the final PDC. All you need to supply is your antibody and standard lab equipment.
Typical CellMosaic personalized PDC kits results in the preparation of approximately 50 nmole of final PDC in buffer with drug-to-protein ratios (DARs) of 2 to 5, averaging DARs of 3-4. Purities are typically over 90% for the conjugates with free or less than 5% of the free payload. Individual results can vary depending on the specific protein system you are using and the hydrophobicity of your payload. Kits instructions are complete and easy to follow, and can typically be carried out within 4 hours (with less than 1-hour hands-on time).
Perkit™ PDC Selection Guide
Product# |
Protein |
Drug |
Scale of Reaction (Standard Kit) |
Labeling Chemistry |
Linkage |
| CM52408 | Any protein | Acid | 15-50 nmol | Surface amine | Stable |
| CM11414 (x1, x3) | Any protein | DM1 | 6.67-20 nmol | Surface amine | Stable |
| CM11430 (x1, x3) | Any protein | SN38 | 6.67-20 nmol | Surface amine | Releasable |
| CM11413 (x1, x3) | Any protein | MMAE | 6.67-20 nmol | Surface amine | Releasable |
| CM11432 (x1, x3) | Any protein | Deruxtecan | 6.67-20 nmol | Surface amine | Releasable |
AqT™ PDC Development & ManufacturingIn the event that an drug conjugate cannot be made using classical linkers or the effectiveness of the drug conjugates are compromised by the number of toxins loaded onto the antibody using CellMosaic PerKits™ PDC, CellMosaic has developed super-hydrophilic and water soluble AqT™ linker for this purpose. Click here for more information. |