Publications and Citations
CellMosaic Publications
Yumei Huang, Shuyan Chen, Binyuan Sun, Amanda Griffin, Nathanial Sweet, Mingqian Feng, Mitchell Ho. Synthesis and evaluation of sugar alcohol-based molecules for drug conjugation and delivery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; April 14–18, 2018; Chicago, IL. Philadelphia (PA): AACR. Cancer Research 2018, 78(13 Suppl): Abstract 755. https://doi.org/10.1158/1538-7445.AM2018-755
Collaboration with the University of New Mexico: Since 2019, CellMosaic has collaborated with Professor Frietze's laboratory to design and synthesize key peptide and drug-of-abuse conjugates for vaccine development.
Isabella G. Romano, Susan B. Core, Naomi R. Lee, Curtis Mowry, Koen K. A. Van Rompay, Yumei Huang, Bryce Chacherain, Kathryn M. Frietze. "A bacteriophage virus-like particle vaccine against oxycodone elicits high-titer and long-lasting antibodies that sequester drug in the blood." Vaccines 2024, 2(3), 471–480.
Isabella G. Romano, Brandi Johnson-Weaver, Susan B. Core, Andzoa N. Jamus, Marcus Brackeen, Bruce Blough, Subhakar Dey, Yumei Huang, Herman Staats, William C. Wetsel, Bryce Chacherain, Kathryn M. Frietze. "Two doses of QB virus-like particle vaccines elicit protective antibodies against heroin and fentanyl." NPJ Vaccines 2025, 10(1), 57. DOI: 10.1038/s41541-025-01105-0.
Selected Customer Publications Using CellMosaic Products and Services
Services
Bioasis Projects: In 2013, CellMosaic prepared numerous single-labeled melanotransferrin protein-antibody conjugates, melanotransferrin peptide-antibody conjugates with defined loading, peptide-HRP-dye triconjugates, and peptide-antibody-dye triconjugates for Bioasis' preclinical research.
George Thom, Mei-Mei Tian, Jon P. Hatcher, Natalia Rodrigo, Matthew Burrell, Ian Gurrell, Timothy Z. Vitalis, Thomas Abraham, Wilfred A. Jefferies, Carl I. Webster, Reinhard Gabathuler. "A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model." Journal of Cerebral Blood Flow & Metabolism 2019, 39(10), 2074–2088. DOI: 10.1177/0271678X18772998.
Kit Products
CM11409 (Antibody MMAE Conjugation Kit with VC-PAB Linkage)
Lofgren, K. A.; Sreekumar, S.; Jenkins, C. E., Jr.; Ernzen, K. J.; Kenny, P. A. Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved amphiregulin in breast cancer. Antibody Therapeutics 2021, 4(4), 252–261. DOI: 10.1093/abt/tbab026
Kierkels, G. J. J.; van Diest, E.; Hernández-López, P.; Scheper, W.; de Bruin, A. C. M.; Frijlink, E.; Aarts-Riemens, T.; van Dooremalen, S. F. J.; Beringer, D. X.; Oostvogels, R.; Kramer, L.; Straetemans, T.; Uckert, W.; Sebestyén, Z.; Kuball, J. Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells. Molecular Therapy: Methods & Clinical Development 2021, 22, 388–400. DOI: 10.1016/j.omtm.2021.06.011
Parameswaran, N.; Luo, L.; Zhang, L.; Chen, J.; DiFilippo, F. P.; Androjna, C.; Fox, D. A.; Ondrejka, S. L.; Hsi, E. D.; Jagadeesh, D.; Lindner, D. J.; Lin, F. CD6-targeted antibody-drug conjugate as a new therapeutic agent for T-cell lymphoma. Leukemia 2023, 37, 2050–2057. DOI: 10.1038/s41375-023-01997-8
Zhang, L.; Luo, L.; Chen, J. Y.; Singh, R.; Baldwin III, W. M.; Fox, D. A.; Lindner, D. J.; Martin, D. F.; Caspi, R. R.; Lin, F. A CD6-targeted antibody-drug conjugate as a potential therapy for T cell-mediated disorders. JCI Insight 2023, 8(23), e172914. DOI: 10.1172/jci.insight.172914
Sun, Z.; Chu, X.; Adams, C.; Ilina, T. V.; Guerrero, M.; Lin, G.; Chen, C.; Jelev, D.; Ishima, R.; Li, W.; Mellors, J. W.; Calero, G.; Dimitrov, D. S. Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate. Molecular Therapy-Oncolytics 2023, 31, 100726. DOI: 10.1016/j.omto.2023.09.002
Hou, J.; Uejima, T.; Tanaka, M.; Lee Son, Y.; Hanada, K.; Kukimoto-Niino, M.; Yamaguchi, S.; Hashimoto, S.; Yokoyama, S.; Takemori, T.; Saito, T.; Shirouzu, M.; Kondo, T. EVA1-antibody drug conjugate is a new therapeutic strategy for eliminating glioblastoma-initiating cells. Neuro-Oncology 2024, 27(3), 682–694. DOI: 10.1093/neuonc/noae226
CM11408 (Antibody SN38 Conjugation Kit)
Micalizzi, D. S.; Che, D.; Nicholson, B. T.; Edd, J. F.; Desai, N.; Lang, E. R.; Toner, M.; Maheswaran, S.; Ting, D. T.; Haber, D. A. Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody. PNAS 2022, 119(43), e2209563119. DOI: 10.1073/pnas.2209563119
CM11431 (Antibody Deruxtecan Conjugation Kit)
Semenova, G.; Frank, S.; Dumpit, R.; Han, W.; Coleman, I.; Gulati, R.; Morrissey, C.; Haffner, M. C.; Nelson, P. S.; Lee, J. K. Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer, Version 1. bioRxiv, September 11, 2025. DOI: 10.1101/2025.09.05.674562
CM52402 (BSA-Peptide Conjugation Kit)
Kleinman, A.; Torres, J.; Wang, B. Evaluation of antibiotic and peptide vaccine strategies for mirror bacterial infections, Version 1. bioRxiv, October 12, 2025. DOI: 10.1101/2025.10.10.681688
CM52411 (KLH-Peptide Conjugation Kit)
Kleinman, A.; Torres, J.; Wang, B. Evaluation of antibiotic and peptide vaccine strategies for mirror bacterial infections, Version 1. bioRxiv, October 12, 2025. DOI: 10.1101/2025.10.10.681688
CM53402 and CM53408 (HRP Oligo Conjugation Kit, Single Label with Thiol Oligo)
Aviñó, A.; Cuestas-Ayllón, C.; Gutiérrez-Capitán, M.; Vilaplana, L.; Grazu, V.; Noé, V.; Balada, E.; Baldi, A.; Félix, A. J.; Aubets, E.; Valiuska, S.; Domínguez, A.; Gargallo, R.; Eritja, R.; Marco, M.-P.; Fernández-Sánchez, C.; Martínez de la Fuente, J.; Ciudad, C. J. Detection of SARS-CoV-2 virus by Triplex Enhanced Nucleic Acid Detection Assay (TENADA). International Journal of Molecular Sciences 2022, 23(23), 15258. DOI: 10.3390/ijms232315258
Gutiérrez-Capitán, M.; Balada, E.; Aviñó, A.; Vilaplana, L.; Galve, R.; Lacoma, A.; Baldi, A.; Alcamí, A.; Noé, V.; Ciudad, C. J.; Eritja, R.; Marco, M.-P.; Fernández-Sánchez, C. Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device. Analytical Chemistry 2025, 97(22), 11863–11873. DOI: 10.1021/acs.analchem.5c01605
CM53403 (AP Oligo Conjugation Kit, Single Label with Amine Oligo)
Schwartz, A. M.; Marcotte, H. A.; Johnson, C. N. Evaluation of Alternative Colony Hybridization Methods for Pathogenic Vibrios. Foods 2023, 12(7), 147. DOI: 10.3390/foods12071472
CM71007 (SepSphere™ Small Molecule Alcohol Immobilization Kit)
Yang, F.; Zhang, D.; Jiang, H.; Ye, J.; Zhang, L.; Bagley, S. J.; Winkler, J.; Gong, Y.; Fan, Y. The small molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine 2023, 15(683), eabq3558. DOI: 10.1126/scitranslmed.abq3558
Reagent Products
CM16001 (Curcumin-β-D-Glucuronide MS Standard)
Chen, W.; Fan-Harvard, P.; Yee, L. D.; Cao, Y.; Stoner, G. D.; Chan, K. K.; Liu, Z. A liquid chromatography-tandem mass spectrometric method for quantification of curcumin-O-glucuronide and curcumin in human plasma. Journal of Chromatography B 2012, 900, 89–93. DOI: 10.1016/j.jchromb.2012.05.026
Cao, Y.; Xu, R. X.; Liu, Z. A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry. Journal of Chromatography B 2014, 949–950, 70–78. DOI: 10.1016/j.jchromb.2013.12.039
CM29101 (SepSphere™ Alprenolol Agarose)
Salom, D.; Padayatti, P. S.; Palczewski, K. Crystallization of G protein-coupled receptors. Methods in Cell Biology 2013, 117, 451–468. DOI: 10.1016/B978-0-12-408143-7.00024-4
Cheong, H. I.; Asosingh, K.; Stephens, O. R.; Queisser, K. A.; Xu, W.; Willard, B.; Hu, B.; Dermawan, J. K. T.; Stark, G. R.; Naga Prasad, S. V.; Erzurum, S. C. Hypoxia sensing through β-adrenergic receptors. JCI Insight 2016, 1(21), e90240. DOI: 10.1172/jci.insight.90240
CM61002 (Biotin-Alprenolol Conjugate)
Rose, J. A.; Wanner, N.; Cheong, H. I.; Queisser, K.; Barrett, P.; Park, M.; Hite, C.; Naga Prasad, S. V.; Erzurum, S.; Asosingh, K. Flow cytometric quantification of peripheral blood cell β-adrenergic receptor density and urinary endothelial cell-derived microparticles in pulmonary arterial hypertension. PLoS One 2016, 11(6), e0156940. DOI: 10.1371/journal.pone.0156940
Christoffersson, G.; Ratliff, S. S.; von Herrath, M. G. Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice. Science Advances 2020, 6(35), eabb2878. DOI: 10.1126/scitranslmed.abq3558
Mohiuddin, I. S.; Wei, S.-J.; Yang, I.-H.; Martinez, G. M.; Yang, S.; Cho, E. J.; Dalby, K. N.; Kang, M. H. Development of a cell-based high-throughput luminescence assay for drug discovery targeting OCT4/DNA-PKcs and OCT4–MK2 interactions. Biotechnology and Bioengineering 2021, 118(5), 1987–2000. DOI: 10.1002/bit.27712
Kaminski, T.; Zhdanov, V. P.; Höök, F. Single-molecule dynamic in-solution inhibition assay: A method for full kinetic profiling of drug candidate binding to GPCRs in native membranes. bioRxiv, September 16, 2021. DOI: 10.1101/2021.09.16.460640
CM92004 (SEC Gel Filtration HPLC Protein Standard, 7 Components, Lyophilized)
Shon, H.; Matveeva, E. A.; Jull, E. C.; Hu, Y.; Coupet, T. A.; Lee, Y.-S. Evidence supporting substrate channeling between domains of human PAICS: A time-course analysis of 13C-bicarbonate incorporation. Biochemistry 2022, 61(7), 575–582. DOI: 10.1021/acs.biochem.1c00803
Collier, G.; Roovers, A. L.; Hulleman, J. D. A spectrum of cysteine mutations in fibulin-3 highlights its disulfide bonding complexity and potential to induce ER stress. Scientific Reports 2025, 15, 30028. DOI: 10.1038/s41598-025-14561-4
Azam, M. S.; Missiakas, D. The signal peptide of staphylococcal protein A alters the multimeric states of PepV. Microbiology Spectrum 2025, e01778-25. DOI: 10.1128/spectrum.01778-25
CM92005 (SEC Gel Filtration HPLC Low Molecular Weight Protein Standard)
Oh, H. B.; Yoon, S. Crystal structures of Campylobacter jejuni CadF reveal a potential role for the arginine residue R268 in peptidoglycan recognition and pocket formation. Scientific Reports 2025, 15, 36733. DOI: 10.1038/s41598-025-20604-7