Conjugation provides a unique method of developing new drugs, new diagnostic reagents, and new tools for studying biological problems. The concept is relatively simple, but the process is very complicated, involving the manipulation of delicate biomolecules with various crosslinking reagents in aqueous environments. At CellMosaic, we have developed advanced conjugation processes involving controlled, site-specific, or single labeling methods to generate single ratio conjugates that are greater than 90% pure. There are two approaches we use to work with our customers/collaborators to achieve their goals.
Fee-for-service approach (service): Conjugation techniques have been developed for decades, evolving into a set of robust chemistries and some well-tested linkers. We will continue using these classical methods and tools to assemble standard conjugates for customers to use or commercialize without the need for licensing. The services we provide include custom synthesis, process development, and manufacturing, as well as bioanalytical, biopurification, and functional group assays.
Reagent development approach (product): For chemicals and conjugates used frequently by customers and for simple conjugation processes that can be developed into ready-to-use kits, we commercialize them as a product at a lower price than the custom service due to the scale of the economy.