For certain biological applications, it may be necessary to introduce functional groups or linkers on a biopolymer. The figure on the left shows how a biopolymer (M1) reacts with a modification agent (M2) and obtains a functional group (FG). CellMosaic routinely carries out biopoilymer modifications with unique functional groups for labeling or conjugation such as aldehyde or thiol functional groups. Introduction of aldehyde groups into biopolymers allows them to react with other molecules specifically at the aldehyde site through reductive amination, oxime, and hydrazone formation. We work with a variety of biopolymers, including antibodies, antibody fragments, enzymes, proteins, peptides and peptidomimetics, DNA, and DNA analogs. For more information regarding functional group introduction, please click here.

CellMosaic can also help prepare fragmented antibodies, such as Fab, Fab', and combination antibody fragments, such as bi-specific antibodies, using a combination of chemical and enzymatic approaches.