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Biopolymer Modification

For certain biological applications, it may be necessary to introduce functional groups or linkers on a biopolymer. The figure on the left shows how a biopolymer (M1) reacts with a modification agent (M2) and obtains a functional group (FG). Over the years, CellMosaic has established a variety of methods for biopolymer modification with unique functional groups for labeling or conjugation, such as aldehyde, keto, maleimide, DBCO, azide, or thiol functional groups. The introduction of aldehyde groups into biopolymers allows them to react with other molecules specifically at the aldehyde site through reductive amination, oxime, and hydrazone formation.  We work with a variety of biopolymers, including antibodies, antibody fragments, enzymes, proteins, peptides and peptidomimetics, DNA, and DNA analogs. For more information regarding functional group introduction, please click here.

CellMosaic also has methods to prepare fragmented antibodies, such as Fab, Fab', and combination antibody fragments, including bi-specific antibodies, using a combination of chemical and enzymatic approaches.