Prepare Your Own Custom Drug-Conjugates for Screening and Proof-of-Concept with CellMosaic’s Personalized Kits (PerKit™)

Since 2017, CellMosaic is providing PerKits™ to help our life science clients quickly evaluate their biologics of interest (antibodies, proteins, peptides, and oligos) with direct conjugations of a range of key payloads (chemotherapeutic drugs and toxins) and traditional linker chemistry. Kits are available in many configurations with a variety of conjugation strategies. Some drug conjugation kits apply to a general payload with certain functional groups such as carboxylic acid and amine. Some supply the selected, standard linkage molecules conjugated to a selected payload, ready with the appropriate reactive modifications to directly attach the payload and linker to your specific biologics of interest. The kits are complete with all reagents and procedures for attaching the selected payload directly to customer's biologics and purifying the final drug conjugates. All customer need to supply is his/her biologics and standard lab equipment.

Perkit™ Drug Conjugation Selection Guide

Product#	Protein	Drug	Scale of Reaction (Standard Kit)	Labeling Chemistry	Linkage
CM11429	IgG Ab	No drug (VC-PAB linker only)	1-3 mg	Reduced thiol	Releasable
CM51403	IgG Ab	Acid	1-3 mg	Surface amine	Stable
CM11410 (x1, x3)	IgG Ab	DM1	1-3 mg	Surface amine	Stable
CM11406 (x1, x3)	IgG Ab	Doxorubicin	1-3 mg	Surface amine	Stable
CM11407 (x1, x3)	IgG Ab	Methotrexate	1-3 mg	Surface amine	Stable
CM11409 (x1, x3)	IgG Ab	MMAE	0.1 mg, 1-3 mg, 30 mg	Reduced thiol	Releasable
CM11422 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Stable
CM11425 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Releasable
CM11408 (x1, x3)	IgG Ab	SN38	1-3 mg, 30 mg	Surface amine	Releasable
CM11431 (x1, x3)	IgG Ab	Deruxtecan	1-3 mg	Reduced thiol	Releasable
CM52408	Any protein	Acid	15-50 nmol	Surface amine	Stable
CM11414 (x1, x3)	Any protein	DM1	6.67-20 nmol	Surface amine	Stable
CM11430 (x1, x3)	Any protein	SN38	6.67-20 nmol	Surface amine	Releasable
CM11413 (x1, x3)	Any protein	MMAE	6.67-20 nmol	Surface amine	Releasable
CM11416 (x1, x3)	F(ab')2	MMAE	0.73-2.2 mg	Surface amine	Stable
CM11419 (x1, x3)	F(ab')2	DM1	0.73-2.2 mg	Reduced thiol	Releasable

(Note: additional kits configurations can be added depending on the request from customers. Please inquire if you do not see your current configuration of interest listed or request a custom bioconjugation service)

Bioconjugate Drug Development & Manufacturing

CellMosaic is a premier service provider, and offers our expertise in all drug conjugations-related services for projects with more complex chemistry, or projects requiring larger product volumes or tighter specifications of the resulting final product. CellMosaic’s services cover all standard, non-proprietary conjugations. For more information, please click here.

AqueaTether^® Technology

In the event that an drug conjugate cannot be made using classical linkers or the effectiveness of the drug conjugates are compromised by the number of toxins loaded onto the antibody, CellMosaic has developed novel super-hydrophilic and high-loading AqueaTether^® (AqT^®) linkers specifically to solve these problems. For more information regarding the AqT^® technologies, please click here. For informaiton how to access this technology for your novel ADC development, please click here.