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Oligonucleotide Labeling

  • Image 1
  • Scheme: oligo labeling through an NHS ester
Custom synthesis, please contact us for a quote.

Oligo nucleotides (DNA or RNA) can be labeled anywhere (3', 5', or via a modified base). The conjugation can be performed in either solid phase or post-synthesis solution phase. Usually a single pure labeled oligo can be obtained. The advantages of our oligo labeling strategy are:

  • Freedom to attach a drug or molecule of interest at any point in the oligo.
  • Other functional groups in the molecule, such as OH, NH2, and SH, will not be affected by the labeling step.

Oligo modification through an amino functional group is the most straightforward labeling method that often used at CellMosaic. Aliphatic primary amine can be introduced to 5' or 3' end of the oligo during synthesis. Exo-cyclic amino groups in Cytosine and Guanine are usually not modified under the reaction conditions. An amino group can also be introduced to the 5'-phosphate via carbodiimide coupling. 

Oligo modification through a thiol functional group is another straightforward labeling method that used at CellMosaic. 

CellMosaic has Personalized Conjugation Kits (PerKit™) for oligo labeling and conjugation based on both thiol and amine chemistry, please click here to learn our PerKit™ product line.

For large scale or project beyond the scope of PerKit™ configuration, please contact us for a quote.

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