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    Main Menu

  • About Us
    • Our History
    • Our Mission
    • Our Approach
    • Our Customers
    • Our Team
    • News
  • Contact Us
  • Products and Services
  • How to Order
    • Ordering Products
      • Terms and Conditions for Sales of Products
    • Ordering Services
    • Shipping & Returns
    • Distributors
  • Technologies
    • AqueaTether™ (AqT™) Technologies
    • oxLink™ and sxLink™ Photocrosslinking Technologies
    • Advanced Conjugation Processes
    • NeIon™ Technologies
  • Resources
    • Custom Conjugation Guide
      • Small Molecule Supply
      • Biopolymer Supply
    • Frequently Asked Questions
    • Introducing Functional Groups
    • Downloadable Documents
  • Careers
  • Shop By Category

  • Antibody-Drug Conjugate (ADC) Kits
    • ADC Kits List
    • ADC Controls
    • ADC Analysis
    • Buffers and others
  • AqueaTether™ (AqT™) Reagents and kits
    • AqT™ Biotin Labeling Kits and Products
    • AqT™ Fluorescence Labeling Kits and Products
    • AqT™ Immobilization Kits and Products
    • AqT™ Therapeutics
  • Drug Conjugation Kits and Solutions
    • Protein-Drug Conjugate (PDC) Kits
  • Personalized Conjugation Kits (PerKit™)
    • Immobilization Kits
    • Oligo Labeling and Conjugation Kits
    • Peptide Labeling and Conjugation Kits
    • Protein Labeling and Conjugation Kits
    • Enzyme Labeling and Conjugation Kits
    • Small Molecule Labeling and Conjugation Kits
    • Antibody Labeling and Conjugation Kits
    • Antibody Fragmentation Kits
    • Antibody Production and Immunoassay Tools
    • Biotin and Streptavidin Labeling
    • Others
  • Standards and Reagents
    • Analytical Standards
    • Assay Kits
    • Drug Intermediates and Metabolites
    • Peptides and Peptide Conjugates
    • Modified Biomolecules and Conjugates
    • Others
  • SERVICES
    • Custom Bioconjugation Service
    • Antibody Drug Conjugates (ADC) Solutions
    • Bioconjugate Drug Development
    • Diagnostic Conjugates Development & Manufacturing
    • Biologics, Bioconjugate Analysis and Purification
    • Other Services
  • Mass Tags
  • OxLink™ and sxLink™ Protein crosslinkers
  • Shop By Brand

  • PerKit™
  • SepSphere™
  • oxLink™
  • sxLink™
  • View all Brands
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  • Login or Sign Up

Shop by Category

  • Antibody-Drug Conjugate (ADC) Kits
    • ADC Kits List
    • ADC Controls
    • ADC Analysis
    • Buffers and others
  • AqueaTether™ (AqT™) Reagents and kits
    • AqT™ Biotin Labeling Kits and Products
    • AqT™ Fluorescence Labeling Kits and Products
    • AqT™ Immobilization Kits and Products
    • AqT™ Therapeutics
  • Drug Conjugation Kits and Solutions
    • Protein-Drug Conjugate (PDC) Kits
  • Personalized Conjugation Kits (PerKit™)
    • Immobilization Kits
    • Oligo Labeling and Conjugation Kits
    • Peptide Labeling and Conjugation Kits
    • Protein Labeling and Conjugation Kits
    • Enzyme Labeling and Conjugation Kits
    • Small Molecule Labeling and Conjugation Kits
    • Antibody Labeling and Conjugation Kits
    • Antibody Fragmentation Kits
    • Antibody Production and Immunoassay Tools
    • Biotin and Streptavidin Labeling
    • Others
  • Standards and Reagents
    • Analytical Standards
    • Assay Kits
    • Drug Intermediates and Metabolites
    • Peptides and Peptide Conjugates
    • Modified Biomolecules and Conjugates
    • Others
  • SERVICES
    • Custom Bioconjugation Service
    • Antibody Drug Conjugates (ADC) Solutions
    • Bioconjugate Drug Development
    • Diagnostic Conjugates Development & Manufacturing
    • Biologics, Bioconjugate Analysis and Purification
    • Other Services
  • Mass Tags
  • OxLink™ and sxLink™ Protein crosslinkers
  • Shop by Brand

  • PerKit™
  • SepSphere™
  • oxLink™
  • sxLink™
  • View all Brands
  • Protein-Drug Conjugate
  • Example 1: Synthesis of a protein-drug conjugate
  • Protein-Drug Conjugate Example 1: Synthesis of a protein-drug conjugate

    Protein-Drug Conjugate

    Please call us to discuss your project

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    SKU:
    CSBL05

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    • Overview

    Product Description

    CellMosaic offers research and development services for bio-pharmaceutical companies that develop recombinant proteins as therapeutics. New target-specific protein drugs can be developed by conjugating drugs or toxins to recombinant proteins. We can also chemically modify or process your recombinant proteins for better clinical performance with PEG or other classical polymers. CellMosaic's scientists have extensive experience in protein conjugation, purification, and modification. For protein that can be changed at the molecular level, we can use cysteine mutagenesis to introduce a single labeling site. For protein that cannot be changed at the molecular level, we look for specific sites that can be modified using chemical methods (site-specific labeling). For protein that have no site-specific labeling sites, we use controlled labeling of surface amines plus advanced purification to obtain single ratio conjugates or near homogeneous multiple ratio conjugates. 

    Advantages of CellMosaic's protein conjugation strategy:

    • Freedom to attach drugs via mulitiple methods.
    • The conjugation strategy can easily be tweaked to couple to different categories of compounds.
    • Short timeline for the development of a bioconjugation strategy.

    Case Studies:

    1. Developing protein-irinotecan drug conjugate for a bio-pharmaceutical company at CellMosaic (shown below): need to conjugate with a very hydrophobic drug. The protein itself is not very stable and easily precipitated after being conjugated. Manage to obtain clean protein-drug conjugate with minimum aggregation. The conjugate shows a characteristic UV spectrum of irinotecan with absorbance maximum at 360 nm.

       

      dc0002-protein-drug-example.jpg

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