CellMosaic offers research and development services for bio-pharmaceutical companies that develop recombinant proteins as therapeutics. New target-specific protein drugs can be developed by conjugating drugs or toxins to recombinant proteins. We can also chemically modify or process your recombinant proteins for better clinical performance with PEG or other classical polymers. CellMosaic's scientists have extensive experience in protein conjugation, purification, and modification. For protein that can be changed at the molecular level, we can use cysteine mutagenesis to introduce a single labeling site. For protein that cannot be changed at the molecular level, we look for specific sites that can be modified using chemical methods (site-specific labeling). For protein that have no site-specific labeling sites, we use controlled labeling of surface amines plus advanced purification to obtain single ratio conjugates or near homogeneous multiple ratio conjugates.
Advantages of CellMosaic's protein conjugation strategy:
Case Studies: