It takes years of hard work and luck to obtain a highly selective small molecule drug. Alternatively, a delivery system properly tailored to carrying potent antitumor drugs can be used. In the mid-1970s, Ringsdorf proposed covalently attaching chemotherapeutic agents to water soluble synthetic polymers for the first time. The advantages of using such polymers are:
Human albumin (HA), polyglutamic acid (PGA), N-hydroxymethyl methacrylamide copolymer (HPMA), poly(lactic-co-glycolic acid) (PLGA), and PEG have been widely tested. CellMosaic helps biopharmaceutical companies developing target-specific small molecule drug conjugates using these classical polymers.
Case Studies: