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      • Terms and Conditions for Sales of Products
    • Ordering Services
    • Shipping & Returns
    • Distributors
  • Technologies
    • AqueaTether™ (AqT™) Technologies
    • oxLink™ and sxLink™ Photocrosslinking Technologies
    • Advanced Conjugation Processes
    • NeIon™ Technologies
  • Resources
    • Custom Conjugation Guide
      • Small Molecule Supply
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    • Buffers and others
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    • AqT™ Fluorescence Labeling Kits and Products
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    • AqT™ Therapeutics
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    • Protein-Drug Conjugate (PDC) Kits
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    • Diagnostic Conjugates Development & Manufacturing
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    • Other Services
  • Mass Tags
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  • sxLink™
  • View all Brands
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Shop by Category

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    • ADC Kits List
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    • Buffers and others
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    • AqT™ Biotin Labeling Kits and Products
    • AqT™ Fluorescence Labeling Kits and Products
    • AqT™ Immobilization Kits and Products
    • AqT™ Therapeutics
  • Drug Conjugation Kits and Solutions
    • Protein-Drug Conjugate (PDC) Kits
  • Personalized Conjugation Kits (PerKit™)
    • Immobilization Kits
    • Oligo Labeling and Conjugation Kits
    • Peptide Labeling and Conjugation Kits
    • Protein Labeling and Conjugation Kits
    • Enzyme Labeling and Conjugation Kits
    • Small Molecule Labeling and Conjugation Kits
    • Antibody Labeling and Conjugation Kits
    • Antibody Fragmentation Kits
    • Antibody Production and Immunoassay Tools
    • Biotin and Streptavidin Labeling
    • Others
  • Standards and Reagents
    • Analytical Standards
    • Assay Kits
    • Drug Intermediates and Metabolites
    • Peptides and Peptide Conjugates
    • Modified Biomolecules and Conjugates
    • Others
  • SERVICES
    • Custom Bioconjugation Service
    • Antibody Drug Conjugates (ADC) Solutions
    • Bioconjugate Drug Development
    • Diagnostic Conjugates Development & Manufacturing
    • Biologics, Bioconjugate Analysis and Purification
    • Other Services
  • Mass Tags
  • OxLink™ and sxLink™ Protein crosslinkers
  • Shop by Brand

  • PerKit™
  • SepSphere™
  • oxLink™
  • sxLink™
  • View all Brands
  • Polymer-Drug Conjugate
  • Example 1: Loading hydrophobic drugs onto a hydrophilic polymer
  • Polymer-Drug Conjugate Example 1: Loading hydrophobic drugs onto a hydrophilic polymer

    Polymer-Drug Conjugate

    Please call us to discuss your project

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    SKU:
    CSBL07

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    Product Description

    It takes years of hard work and luck to obtain a highly selective small molecule drug. Alternatively, a delivery system properly tailored to carrying potent antitumor drugs can be used. In the mid-1970s, Ringsdorf proposed covalently attaching chemotherapeutic agents to water soluble synthetic polymers for the first time. The advantages of using such polymers are:

    • Increased solubility and stability of hydrophobic drugs.
    • More drug delivered to the tumor tissue.
    • Enhanced tumor specificity by the addition of a targeting residue.
    • Fewer undesirable side effects and reduced frequency of dosing.

    Human albumin (HA), polyglutamic acid (PGA), N-hydroxymethyl methacrylamide copolymer (HPMA), poly(lactic-co-glycolic acid) (PLGA), and PEG have been widely tested. CellMosaic helps biopharmaceutical companies developing target-specific small molecule drug conjugates using these classical polymers. 

    Case Studies:

    1. Loading hydrophobic drugs onto a hydrophilic polymer at CellMosaic (shown below).
      • Challenge: Very hydrophobic small molecule drugs. The drug has serveral OH groups that may interfere with the conjugation. The loading capacity onto the polymer needs to be as high as 20% (w/w).
      • Modification strategies for small drugs: Small drugs were first modified site-specifically with a single reactive amine group. 
      • Result: 20% drugs are loaded onto the polymer (w/w) without any precipitation in water. The procedure is easy to scale up.  dc0005-example.jpg

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