Angiotensin II is the main effector peptide of the renin-angiotensin system. Angiotensin II binds two major receptors: the angiotensin II type-1 (AT₁) receptor and type-2 (AT₂) receptor.

Chemical Information

• Chemical name: angiotensin II (1-8)
• Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe (or DRVYIHPF)
• C-terminus: free acid;                   N-terminus: free amine
• Counter ion: trifluoroactate salt;    Chemical formula: C₅₀H₇₁N₁₃O₁₂
• Molecular weight:1046.19;           CAS number: 4474-91-3

Specification

• Physical appearance: lyophilized powder;         Storage temp.: -20 °C
• Purity: ≥ 96 % by HPLC

References

Recent reviews for Ang II:

1. Lacolley P, Safar ME, Regnault V, Frohlich ED, AM J Physiol Heart Circ Physiol. 2009, 297, H1567-1575; 2. Palomeque J, Delbridge L, Petroff MV. Front Biosci. 2009 Jun 1;14:5118-33; 3. Chu KY, Leung PS. Curr Protein Pept Sci. 2009 Feb;10(1):75-84; 4. de Cavanagh EM, Ferder M, Inserra F, Ferder L. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H550-8.