Angiotensin IV is an endogenous agonist for the AT4 receptor (insulin-regulated aminopeptidase). It can be generated from Ang III by aminopeptidase M.

Chemical Information

• Chemical name: angiotensin IV
• Sequence: Val-Tyr-Ile-His-Pro-Phe (or VYIHPF)
• C-terminus: free acid;                   N-terminus: free amine
• Counter ion: trifluoroactate salt;    Chemical formula: C₄₀H₅₄N₈O₈
• Molecular weight: 774.92;           CAS number: 23025-68-5

Specification

• Physical appearance: lyophilized powder;         Storage temp.: -20 °C
• Purity: ≥97% by HPLC

References

Recent reviews for Ang IV:

1. Stragier B, De Bundel D, Sarre S, Smolders I, Vauquelin G, Dupont A, Michotte Y, Vanderheyden P. Heart Fail Rev. 2008 Sep;13(3):321-37; 2. Chai SY, Fernando R, Peck G, Ye SY, Mendelsohn FA, Jenkins TA, Albiston AL. Cell Mol Life Sci. 2004Nov;61(21):2728-37; 3. von Bohlen und Halbach O. Cell Tissue Res. 2003 Jan;311(1):1-9.