Product Description
| Download Documents | |
| Product Sheet | |
| SDS | COA_Lot#0528E |
Trastuzumab, also known as Herceptin, is a human monoclonal antibody that targets the HER2/c-neu receptor of the ErbB family of tyrosine kinase receptors. Recognized for its efficacy against HER2-positive cancers, Trastuzumab is widely used in the treatment of HER2-positive breast and gastric cancers—either as monotherapy in immunotherapy or in combination with conjugated targeted therapies such as ado-trastuzumab emtansine and trastuzumab Deruxtecan. It has been proven to be a promising biologic agent in cancer treatment.
CellMosaic’s Trastuzumab Biosimilar is a research-grade biologic equivalent of anti-HER2 monoclonal antibody, designed to support research involving Trastuzumab. The product mimics the efficacy and mechanism of action of the original Trastuzumab. It serves as a suitable alternative for anti-HER2 antibody research, effectively controlling HER2 overexpression by inhibiting cellular proliferation, replication, and downstream signaling pathways. This product is provided as 25 μg aliquots of lyophilized solid, ready to use after reconstitution with sterilized water. It is suitable for ELISA assays and studying Trastuzumab-related biological mechanisms.
The product is sold as 1 vial of 25 microgram (Cat# CM51000-25UG), and 4 vials of 25 microgram (Cat# CM51000-100UG). For bulk orders, please contact us for a quote.
Antibody Information
- Molecular Weight: 150 KDa
- Immunogen: HER2/c-neu receptor (ErbB family)
- Expression Host: CHO stable cell line (biosimilar to trastuzumab)
- Class: Human IgG1, Kappa
- Antibody Type: Monoclonal
- Purity: 95-100% by SEC HPLC Analysis (refer to specific lot for actual purity)
- Physical Appearance: Colorless to white lyophilized powder in a microcentrifuge tube
Key Features of the Product
- Lyophilized solid from a sterile buffer (approx. pH 6.0) containing sugar-based stabilizers; no preservatives
- Ready to use upon reconstitution with sterile deionized water
- Accurate protein quantification by UV/HPLC
- Endotoxin level: ≤0.1 EU per 1 mg of the antibody (LAL method)
- Suitable for use in ELISA assays and studying the effects Trastuzumab related biological pathways.
Applications
- Neutralization, functional assays, antibody engineering or development
- ELISA, FACS, IF, IHC, in vivo studies, IP, WB.
- Serves as a quantitative or qualitative control standard in assays
Example SEC and HIC HPLC Profiles of Trastuzumab Biosimilar
Lot number: S609.S6.0528E
Figure 1: Representative size-exclusion HPLC (SEC-HPLC) profile of Trastuzumab Biosimilar (Human anti-HER2 mAb, Product: CM51000), demonstrating no detectable aggregation and ≥99% purity.
Figure 2: Representative hydrophobic interaction chromatography (HIC-HPLC) profile of Trastuzumab Biosimilar (human anti-HER2 mAb, Product: CM51000), demonstrating near homogeneity of the antibody.
Frequently Asked Questions:
If you can’t find the answer you’re looking for or need information on general topics, please visit the main Frequently Asked Questions (FAQs) section.
