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    • S-Methyl DM1 (S-Methyl Mertansine) Standard
  • S-Methyl DM1 (S-Methyl Mertansine) Chemical Structure
  • S-Methyl DM1 (S-Methyl Mertansine) Chemical Structure

    S-Methyl DM1 (S-Methyl Mertansine) Standard

    MSRP:
    Now: $273.00
    (You save )
    SKU:
    CM11016
    Availability:
    In stock, usually ships within 24 hrs
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    • Buy 3 - 4 and get 5% off
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    • Overview

    Product Description

    Download Documents
    Product Sheet
    SDS COA_Lot#NB0320702

    S-methyl DM1 is the primary cellular or liver metabolite of ADC or other conjugates prepared with DM1. DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare antibody-drug conjugates, such as trastuzumab emtansine (abbreviated as T-DM1). DM1 is not very stable in aqueous solution and can be oxidized or dimerized.

    CellMosaic’s S-methyl DM1 is a high purity product that can serve as a standard for HPLC and LC-MS/MS analysis. The product is formulated in DMSO solution, quantified by UV/HPLC using DM1 as standard/calibrator at 252 nm, and ready to use after dilution. Although S-methyl DM1 inhibits polymerization weaker than DM1, it can also be used as a stable control for ADC studies instead of DM1.

    The product is sold as 1 vial of 1 mg (133 uL x 10 mM). If you would like to buy multiple vials, please check our Bulk Pricing:Buy in bulk and save


    Chemical Information

    • Chemical name: S-Methyl DM1 (S-Methyl Mertansine)
    • Synonym: N2'-deacetyl-N2'-(3-methylthio-1-oxopropyl)-maytansine
    • Chemical formula: C36H50ClN3O10S
    • Molecular weight: 752.32 Da
    • CAS number: 912569-84-7

    Specifications

    • Physical appearance: solution
    • Storage temp.: -20 °C
    • Purity: ≥ 98 % by C18 HPLC
    • Concentration: 10 mM in DMSO (determined by UV/HPLC using DM1 as standard/calibrator at 252 nm)

    References

    • Lopus M. et al. (2010). Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. Mol. Cancer. Ther. 9(1), 2689-2699.
    • Oroudjev E. et al. (2010). Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability. Cancer Ther. 9(10), 2700-2713.
    • Davis J.A. et al. (2012) In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. Drug Metabolism and Disposition 40(10), 1927-1934.

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