DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare antibody-drug conjugates, such as trastuzumab emtansine (abbreviated as T-DM1). This BSA-DM1 conjugate is designed with similar linker chemistry as T-DM1 and is synthesized at CellMosaic for our customers' usage in immunization or immunoassay. Maleimide functional groups are first introduced to the BSA followed by reaction of the maleimide group with the thiol of DM1 to form the conjugate. The final conjugate is lyophilized from phosphate buffered saline containing sugar-based stabilizer for easy shipping and storage.
The product is sold as either 1 vial of 1 mg (Cat# CM52110_1MG) or 5 vials of 1 mg (Cat# CM52110_5MG). For bulk orders, please contact us for a quote.
- Chemical name: BSA-DM1 (Mertansine) Conjugate
- Chemical formula: N/A
- Molecular weight: 70KDa; CAS number: N/A
- Physical appearance: white to off-white preservative-free lyophilized powder in a 2.0 mL centrifuge tube
- Storage temp.: -20 °C
- Purity: ≥ 99 % of conjugates by HPLC
- Drug over BSA ratio: ~4