Oligo—Antibody Conjugate

Price:

The standard price is $2100 for 3 mg of starting biopolymers. Please contact us for a quotation.

SKU:

BC0007

Chemistry: Antibody is thiolated with 2-iminothiolane and then reacted with a maleimide-activated oligo.
Specification: A pool of heterogeneous products.
Procedure: After a buffer exchange (if necessary), labeling of amine modified-oligo with NHS ester-maleimide followed by gel filtration to remove excess crosslinking reagents. Then thiolation of antibody followed by conjugation of antibody to maleimide -activated oligo and purification. Finally, concentration determination and gel electrophoresis analysis of the oligo-antibody conjugates.
Price: Standard price covers labor and materials including the cost of maleimide -activated oligo preparation, antibody thiolation, conjugation procedure, conjugate purification and analysis.
Starting materials: Please check biopolymer for ordering information.
Note: In this case sulfhydryl functional groups will be introduced to an antibody through Lys residues using a reliable and reproducible procedure. However, if some of the modified or conjugated Lys residues are located on the antigen binding sites, this method may produce partially active or inactive antibody-enzyme conjugates that may not bind to the antigen. In such a case an alternative conjugation method may be used.