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ADC and Other Drug Conjugate (ODC) Solutions

Prepare Your Own Custom Drug-Conjugates for Screening and Proof-of-Concept with CellMosaic’s Personalized Kits (PerKit™)

Since 2017, CellMosaic is providing PerKits™ to help our life science clients quickly evaluate their biologics of interest (antibodies, proteins, peptides, and oligos) with direct conjugations of a range of key payloads (chemotherapeutic drugs and toxins) and traditional linker chemistry. Kits are available in many configurations with a variety of conjugation strategies. Some drug conjugation kits apply to a general payload with certain functional groups such as carboxylic acid and amine. Some supply the selected, standard linkage molecules conjugated to a selected payload, ready with the appropriate reactive modifications to directly attach the payload and linker to your specific biologics of interest. The kits are complete with all reagents and procedures for attaching the selected payload directly to customer's biologics and purifying the final drug conjugates. All customer need to supply is his/her biologics and standard lab equipment.

Perkit™ Drug Conjugation Selection Guide

Scale of Reaction (Standard Kit)
Labeling Chemistry
 CM11429 IgG Ab No drug (VC-PAB linker only) 1-3 mg Reduced thiol Releasable
 CM51403  IgG Ab  Acid  1-3 mg Surface amine  Stable 
 CM11410 (x1, x3)  IgG Ab  DM1  1-3 mg Surface amine  Stable 
 CM11406 (x1, x3)  IgG Ab  Doxorubicin  1-3 mg Surface amine  Stable 
 CM11407 (x1, x3)  IgG Ab  Methotrexate  1-3 mg Surface amine  Stable 
 CM11409 (x1, x3)  IgG Ab  MMAE  0.1 mg, 1-3 mg  Reduced thiol  Releasable 
 CM11422 (x1, x3)  IgG Ab  MMAF  1-3 mg  Reduced thiol  Stable 
 CM11425 (x1, x3)  IgG Ab  MMAF  1-3 mg  Reduced thiol  Releasable 
 CM11408 (x1, x3)  IgG Ab  SN38  1-3 mg Surface amine  Releasable 
 CM11431 (x1, x3)  IgG Ab Deruxtecan  1-3 mg  Reduced thiol  Releasable
 CM52408 Any protein   Acid  15-50 nmol Surface amine  Stable 
 CM11414 (x1, x3) Any protein   DM1  6.67-20 nmol Surface amine  Stable 
 CM11430 (x1, x3) Any protein   SN38  6.67-20 nmol Surface amine  Releasable 
 CM11413 (x1, x3) Any protein   MMAE  6.67-20 nmol Surface amine  Releasable 
 CM11416 (x1, x3)  F(ab')2  MMAE  0.73-2.2 mg Surface amine  Stable 

 CM11419 (x1, x3)

 F(ab')2  DM1  0.73-2.2 mg Reduced thiol  Releasable
(Note: additional kits configurations can be added depending on the request from customers. Please inquire if you do not see your current configuration of interest listed or request a custom bioconjugation service)


Bioconjugate Drug Development & Manufacturing

CellMosaic is a premier service provider, and offers our expertise in all drug conjugations-related services for projects with more complex chemistry, or projects requiring larger product volumes or tighter specifications of the resulting final product. CellMosaic’s services cover all standard, non-proprietary conjugations. For more information, please click here.

AqueaTether® Technology

In the event that an drug conjugate cannot be made using classical linkers or the effectiveness of the drug conjugates are compromised by the number of toxins loaded onto the antibody, CellMosaic has developed novel super-hydrophilic and high-loading AqueaTether® (AqT®) linkers specifically to solve these problems. For more information regarding the AqT® technologies, please click here. For informaiton how to access this technology for your novel ADC development, please click here.