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Streptavidin/Avidin
Streptavidin is a tetrameric protein containing four biotin-binding sites, one on each subunit. The streptavidin/avidin-biotin system is one of the most widely used affinity-based technologies in biochemistry, molecular biology, diagnostics, and bioconjugation. The avidin/streptavidin-biotin interaction is among the strongest non-covalent interactions known in nature, with a dissociation constant (Kd) of approximately 10^-14 to 10^-15 M.
Because biotin can be readily introduced into proteins, antibodies, peptides, oligonucleotides, and other biomolecules, streptavidin serves as a versatile molecular connector that enables highly modular assay and conjugation platforms. Major applications of the streptavidin/avidin-biotin system include ELISA assays utilizing streptavidin-HRP detection, immunohistochemistry (IHC), nucleic acid detection, affinity purification, biomolecule immobilization on streptavidin-coated surfaces, and signal amplification technologies.
CellMosaic offers a broad range of streptavidin- and avidin-based labeling and bioconjugation reagents, including PerKit®, that are fully compatible with AqT® biotinylation reagents. In addition to our catalog products, we provide custom synthesis and bioconjugation services to support diverse research, diagnostic, and therapeutic applications involving streptavidin, avidin, and monovalent streptavidin technologies.