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    • Bioconjugate Drug Development & Manufacturing
    • Polymer-Drug Conjugate
  • Depiction of drug molecules attached to a polymer
  • Example 1: Loading hydrophobic drugs onto a hydrophilic polymer
  • Depiction of drug molecules attached to a polymer Example 1: Loading hydrophobic drugs onto a hydrophilic polymer

    Polymer-Drug Conjugate

    Custom synthesis, please contact us for a quote.

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    SKU:
    CSBL07

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    • Overview

    Product Description

    As an alternative to the years of hard work and luck nescessary to obtain a highly selective small molecule drug, a delivery system properly tailored to carrying potent antitumor drugs can be used. In the mid-1970s, Ringsdorf, a polymer chemist, proposed covalently attaching chemotherapeutic agents to water soluble synthetic polymers for the first time.

    Advantages of using polymers for delivering chemotherapeutic agents:

    • Increased solubility and stability of hydrophobic drugs.
    • More drug delivered to the tumor tissue.
    • Enhanced tumor specificity by the addition of a targeting residue.
    • Fewer undesirable side effects and reduced frequency of dosing.

    CellMosaic® helps biopharmaceutical companies develop target-specific small molecule drug conjugates using these classical polymers. Human albumin (HA), polyglutamic acid (PGA), N-hydroxymethyl methacrylamide copolymer (HPMA), poly(lactic-co-glycolic acid) (PLGA), and PEG have been widely tested.

    Case Studies:

    1. Loading hydrophobic drugs onto a hydrophilic polymer at CellMosaic® (shown below).
      • Challenge: Very hydrophobic small molecule drugs. The drug has serveral OH groups that may interfere with the conjugation. The loading capacity onto the polymer needs to be as high as 20% (w/w).
      • Modification strategies for small drugs: Small drugs were first modified site-specifically with a single reactive amine group. 
      • Result: 20% drugs are loaded onto the polymer (w/w) without any precipitation in water. The procedure is easy to scale up. 

    Loading hydrophobic drugs onto a hydrophilic polymer at CellMosaic®

    Product Videos

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      Other Drug Conjugates

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