At CellMosaic, we routinely synthesize oligo-peptide conjugates for customers, in particularly, the ones that customers have difficulties in obtaining themselves due to the properties of the starting oligos or peptides. We use various strategies to obatin a site-specific labeled oligo-peptide. The routine method we use is to utilize an N-terminal Cys incorporated peptide to react with a maleimide activated oligo. If the peptide has an internal Cys, we can use other strategies such as oxime formation through a hydroxyl-amine modified peptide reaction with an aldehyde modified oligo.
CellMosaic has Personalized Conjugation Kits (PerKit™) for peptide and oligo conjugation via thiol maleimide coupling (Cat# CM42301).
For large scale or project beyond the scope of PerKit™ configuration, please contact us for a quote.
Examples (see images):