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HRP-MMAE (1:2) Conjugate

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Price:
$499.00
SKU:
CM53210-0.5MG
Availability:
In stock, usually ships within 24 hrs
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Calculated at checkout
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SDS COA_Lot#S17P2.072820

MMAE (monomethyl auristatin E) is an antimitotic agent that binds tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that containing a cathepsin clevable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics). This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and is synthesized at CellMosaic for our customers' usage in Horseradish peroxidase (HRP) based assay. A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding.

The final conjugate is purified to obtain two MMAE-labeled HRP conjugates, and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage. 

The product is sold as 1 vial of 0.5 mg (Cat# CM53210_0.5MG) or 4 vials of 0.5 mg (Cat# CM53210_2MG). For bulk orders, please contact us for a quote.


Chemical Information

  • Chemical name: HRP-MMAE (monomethyl auristatin E) (1:2) Conjugate
  • Chemical formula: N/A
  • Molecular weight: 47KDa           CAS number: N/A

Specification

  • Physical appearance: brownish preservative-free lyophilized powder in a 1.5 mL centrifuge tube
  • Storage temp.: -20 °C
  • Purity: ≥ 99 % of two MMAE labeled conjugates by HPLC
  • Activity: ≥66 units/mg protein [Unit Definition: one unit is the amount of enzyme that will  form 1.0 mg purpurogallin from pyrogallol in 20 sec. at pH 6.0 at 20 °C]
  • Drug to HRP ratio: 2

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