Product Description
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|---|---|
| Product Sheet | |
| SDS | COA (Lot S17P1.072820) |
MMAE (monomethyl auristatin E) is an antimitotic agent that binds tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that contains a cathepsin clevable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics). This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and PDC prepared by our customer using CellMosaic’s Antibody MMAE Conjugation Kit (Cat#: CM11409) and Protein MMAE Conjugation Kit (Cat#: CM11413). It is synthesized at CellMosaic® for our customers' usage in horseradish peroxidase (HRP) based assay. A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding.
The final conjugate is purified to obtain a single MMAE-labeled HRP conjugate and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage.
The product is sold as 1 vial of 0.5 mg (Cat# CM53209-0.5MG) or 4 vials of 0.5 mg (Cat# CM53209-2MG). For bulk orders, please contact us for a quote.
Chemical Information
- Chemical name: HRP-MMAE (horseradish peroxidase-monomethyl auristatin E) (1:1) Conjugate
- Chemical formula: N/A
- Molecular weight: 44KDa CAS number: N/A
Specification
- Physical appearance: brownish preservative-free lyophilized powder in a 1.5 mL centrifuge tube
- Storage temp.: at or below -20 °C
- Purity: ≥ 99 % of single MMAE-labeled conjugates by HPLC
- Activity: ≥110 units/mg protein [Unit Definition: one unit is the amount of enzyme that will form 1.0 mg purpurogallin from pyrogallol in 20 sec. at pH 6.0 at 20°C]
- Drug to HRP ratio: 1
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