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    • Drug Conjugation Kits and Solutions

    Prepare Your Own Custom Drug-Conjugates for Screening and Proof-of-Concept with CellMosaic’s Personalized Kits (PerKit™)

    CellMosaic is now providing PerKits™ to help our life science clients quickly evaluate their biologics of interest (antibodies, proteins, peptides, and oligos) with direct conjugations of a range of key payloads (chemotherapeutic drugs and toxins) and traditional linker chemistry. Kits are available in many configurations with a variety of conjugation strategies.

    Some drug conjugation kits apply to a general payload with certain functional groups such as carboxylic acid and amine. Some supply the selected, standard linkage molecules conjugated to a selected payload, ready with the appropriate reactive modifications to directly attach the payload and linker to your specific biologics of interest. The kits are complete with all reagents and procedures for attaching the selected payload directly to your biologics and purifying the final drug conjugates. All you need to supply is your biologics and standard lab equipment.

    Drug Conjugation Service

    CellMosaic is a premier service provider, and offers our expertise in all drug conjugations-related services for projects with more complex chemistry, or projects requiring larger product volumes or tighter specifications of the resulting final product. CellMosaic’s services cover all standard, non-proprietary conjugations.

    AqueaTether™ Technology

    In the event that an drug conjugate cannot be made using classical linkers or the effectiveness of the drug conjugates are compromised by the number of toxins loaded onto the antibody, AqueaTether ™ Therapeutics, a separate division of CellMosaic, has developed novel super-hydrophilic and high-loading AqueaTether ™ linkers specifically to solve these problems. 

    Limited quantities of  AqT™ADC and PDC Evaluation Kits are currently developed for customer to perform conjugations in-house and evaluate the benefit of AqT™ linkers for ADC on a small scale. For more information, please click here. 

     

    Perkit™ Drug Conjugation Selection Guide

    Product#
    Protein
    Drug
    Scale of Reaction (Standard Kit)
    Labeling Chemistry
    Linkage
     CM11429 IgG Ab No drug (VC-PAB linker only) 1-3 mg Reduced thiol Releasable
     CM51403  IgG Ab  Acid  1-3 mg Surface amine  Stable 
     CM11410 (x3)  IgG Ab  DM1  1-3 mg Surface amine  Stable 
     CM11406 (x3)  IgG Ab  Doxorubicin  1-3 mg Surface amine  Stable 
     CM11407 (x3)  IgG Ab  Methotrexate  1-3 mg Surface amine  Stable 
     CM11409 (x3)  IgG Ab  MMAE  0.1 mg, 1-3 mg, 30 mg  Reduced thiol  Releasable 
     CM11422 (x3)  IgG Ab  MMAF  1-3 mg  Reduced thiol  Stable 
     CM11425 (x3)  IgG Ab  MMAF  1-3 mg  Reduced thiol  Releasable 
     CM11408 (x3)  IgG Ab  SN38  1-3 mg, 30 mg Surface amine  Releasable 
     CM11431 (x3)  IgG Ab Deruxtecan  1-3 mg  Reduced thiol  Releasable
     CM52408 Any protein   Acid  15-50 nmol Surface amine  Stable 
     CM11414 (x3) Any protein   DM1  6.67-20 nmol Surface amine  Stable 
     CM11413 (x3) Any protein   MMAE  6.67-20 nmol Surface amine  Releasable 
     CM11416 (x3)  F(ab')2  MMAE  0.73-2.2 mg Surface amine  Stable 

     CM11419 (x3)

    		  F(ab')2  DM1  0.73-2.2 mg Reduced thiol  Releasable
    (Note: additional kits configurations can be added depending on the request from customers. Please inquire if you do not see your current configuration of interest listed or request a custom bioconjugation service)

     

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