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Drug Conjugation Kits and Solutions

Prepare your own custom drug-conjugates for screening and proof-of-concept with CellMosaic’s Personalized Kits (PerKit™)

CellMosaic is now providing PerKits™ to help our life science clients quickly evaluate their biologics of interest (antibodies, proteins, peptides, and oligos) with direct conjugations of a range of key payloads (chemotherapeutic drugs and toxins) and traditional linker chemistry. Kits are available in many configurations with a variety of conjugation strategies.

Some drug conjugation kits apply to a general payload with certain functional groups such as carboxylic acid and amine. Some supply the selected, standard linkage molecules conjugated to a selected payload, ready with the appropriate reactive modifications to directly attach the payload and linker to your specific biologics of interest. The kits are complete with all reagents and procedures for attaching the selected payload directly to your biologics and purifying the final drug conjugates. All you need to supply is your biologics and standard lab equipment.

Service: CellMosaic is a premier service provider, and offers our expertise in all drug conjugations-related services for projects with more complex chemistry, or projects requiring larger product volumes or tighter specifications of the resulting final product. CellMosaic’s services cover all standard, non-proprietary conjugations.

AqueaTether ™ Technology: In the event that an drug conjugate cannot be made using classical linkers or the effectiveness of the drug conjugates are compromised by the number of toxins loaded onto the antibody, AqueaTether ™ Therapeutics, a separate division of CellMosaic, has developed novel super-hydrophilic and high-loading AqueaTether ™ linkers specifically to solve these problems. To explore this opportunity and learn more about AqueaTether ™ platform technologies, please visit our website at aqttherapeutics.com

 

List of Perkit™ Drug Conjugations

Product#

Protein

Drug

Scale of Reaction

Labeling Chemistry

Linkage

CM51403 IgG Ab Acid 1-3 mg Surface amine Stable 
CM11410 (x3) IgG Ab DM1 1-3 mg Surface amine Stable 
CM11406 (x3) IgG Ab Doxorubicin 1-3 mg Surface amine Stable 
CM11407 (x3) IgG Ab Methotrexate 1-3 mg Surface amine Stable 
CM11409 (x3) IgG Ab MMAE 1-3 mg Reduced thiol Releasable 
CM11422 (x3) IgG Ab MMAF 1-3 mg Reduced thiol Stable 
CM11425 (x3) IgG Ab MMAF 1-3 mg Reduced thiol Releasable 
CM11408 (x3) IgG Ab SN38 1-3 mg Surface amine Releasable 
CM52408 Any protein  Acid 15-50 nmole Surface amine Stable 
CM11414 (x3) Any protein  DM1 4-20 nmole Surface amine Stable 
CM11413 (x3) Any protein  MMAE 4-20 nmole Surface amine Releasable 
CM11419 (x3) F(ab')2 MMAE 0.73-2.2 mg Surface amine Stable 
CM11416 (x3) F(ab')2 DM1 0.73-2.2 mg Reduced thiol Releasable

  (Note: additional kits configurations will be added as needed. Please inquire if you do not see your current configuration of interest listed)