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PerKit™ Antibody Drug Conjugation Kit (Carboxylic Acid)

  • Antibody drug conjugates
Price:
$650.00
SKU:
CM11401
Availability:
In stock, usually ships within 1-3 days
Shipping:
Calculated at checkout
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SDS USER MANUAL

This is a personalized conjugation kit (PerKit™) for antibody (IgG) labeling of a chemotherapeutic drug or toxin containing carboxylic acid (-COOH) functional groups. Using the kit components, the customer converts the carboxylic acid to an activated N-hydroxysuccinimide (NHS) ester, followed by reaction with the surface amino groups of the IgG to form a stable amide bond. The final product is purified to remove any unreacted drug. 

This kit provides materials to label one antibody. Scale of the reaction: 3 mg.


Requirement for Small Molecule

  • Preferably > 90% pure
  • Absence of primary or secondary amine (-NH2) groups
  • Preferably contains only one non-hindered aliphatic carboxylic acid (-COOH)
  • For molecule containing aromatic carboxylic acid, hindered aliphatic carboxylic acid, or hydroxyl (-OH) groups, please consult CellMosaic first before placing the order.

Key Features of this PerKit™

  • Offers a simple and easy way to label IgG with any small molecule containing carboxylic acid
  • Fast and easy preparation: 4 h preparation and <30 minutes hands-on time
  • All reagents and supplies included for preparation and purification
  • Over 90% pure conjugated products by SEC
  • Options to choose tailored services at CellMosaic prior to and after conjugation

Prior to conjugation: you can upload your small molecule information when you place your order. CellMosaic will general a PerKit™ sheet containing calculation, chemical structure, MW of your final conjugate, and recommendations for the conjugation if your molecule has special features. 

After conjugation: you can choose to send your sample to CellMosaic for HPLC analysis.


Protocol

cm51403-scheme.png

 


Labeling Chemistry

cm11401-antibody-drug-acid-conjugation-scheme.png 

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