CellMosaic's scientists have extensive experience in the bioconjugation field and have published numerous patents and papers in antibody, peptide, and oligonucleotide based bioconjugation. We also work with various leading industry and academic consultants to ensure our competitive advantage in the bioconjugate field.
Yumei Huang, PhD — Founder, President & CEO
Dr. Huang has over eighteen years of research experience in chemistry and biology with extensive knowledge of conjugation chemistry. From 2005 to 2009, Dr. Huang initiated and developed the core chemical technologies based on DNA-programmed chemistry for gene detection and protein diagnostics at Ensemble Therapeutics (Cambridge, MA). Previously, Dr. Huang worked at Johnson Matthey Pharma Services (Devens, MA), developing the process for APIs for various clients. Dr. Huang obtained her Ph.D. in bioorganic chemistry at Case Western Reserve University (Cleveland, OH) from Professor Philip P. Garner. Her thesis title was "Development of Antisense Alpha-helical Peptide Nucleic Acid". Dr. Huang conducted her postdoctoral studies under Nobel Laureate H. Gobind Khorana, Professor of Biology and Chemistry at Massachusetts Institute of Technology (Cambridge, MA). Her postdoctoral research was focused on developing new chemical methodologies for studying protein—protein interactions in membrane proteins. Dr. Huang also has an M.S. degree in organic chemistry from the Graduate University of the Chinese Academy of Sciences (also known as Graduate School in Beijing, University of Science and Technology of China) and a B.S. degree in organic chemistry from NanKai University (Tianjin, China).
Shuyan Chen, PhD — Director of Biology
Dr. Chen joined CellMosaic in March 2011 with over eighteen years of research experience in biochemistry, molecular biology, structural biology, and chemistry. Prior to working at CellMosaic, Dr. Chen studied the control of DNA replication initiation with Professor Stephen P. Bell at Howard Hughes Medical Institute / Massachusetts Institute of Technology. She initiated a project to develop a partially reconstituted in vitro assay for pre-replicative complex (pre-RC) formation and studied interactions between replication proteins during pre-RC assembly and the molecular mechanism by which cyclin-dependent kinase inhibits pre-RC formation. Dr. Chen obtained her Ph.D. in Bioorganic Chemistry from Brandeis University (Waltham, MA). Her thesis title was “A Tale of Two Structures: Determinants of DNA Binding by DtxR and 3’ Splice Site Selection by the Human Spliceosome”. She studied the diphtheria toxin repressor in complex with its consensus DNA binding sequence using X-ray crystallography with Professor Dagmar Ringe, and the mechanism of pre-mRNA splicing with Professor Melissa J. Moore. Dr. Chen completed her Bachelor of Science research with Professor Yunyu Shi at the University of Science and Technology of China (Hefei, China) using path integral molecular dynamics to simulate plastocyanin at different temperatures. Dr. Chen is also a USPTO registered patent agent and currently managing CellMosaic’s IP portfolio along with outsider patent counsel and consultants.
Outside Patent Counsel — Philip Zhang, PhD, J.D., Esq.