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Fab Mertansine (DM1) Conjugation Kit

  • Fab DM1 conjugate CM11418
  • Mertansine (DM1) Chemical Structure
Price:
$990.00
SKU:
CM11418
Availability:
Custom kit made to order, usually ships within 1 week
Shipping:
Calculated at checkout
Quantity:


 

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SDS USER MANUAL CM11418

CellMosaic has designed this kit for any Fab labeling of mertansine (DM1) with SMCC (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate) linker for early stage screening of your antibody.

This kit includes SMCC and DM1, which can be coupled to the Fab sequentially via surface amines (a method developed by Immunogen). The product is purified to remove any unreacted drug. 

This kit provides materials to label either one or three Fabs. Reaction scale: 1 mg

Shipping policy: heat-sensitive, choose overnight (ships Mon.-Thur.) or 2-day delivery (ships Mon.-Wed.) at checkout.


Drug Information

  • Name: Mertansine (DM1) 
  • CAS number: 139504-50-0
  • Mechanism of action: Inhibits cell division by blocking the polymerisation of tubulin

Key Features of this PerKit™

  • Offers a simple and easy way to label Fab with DM1 with minimum exposure to the toxin
  • Stable linkage 
  • Fast and easy preparation: 6 h preparation and <2 h hands-on time
  • All reagents and supplies included for preparation and purification
  • Average 2-4 DM1 labeling per Fab
  • Options to choose tailored services at CellMosaic after conjugation

After conjugation: you can choose to send your sample to CellMosaic for HPLC analysis and determination of the DOL.

 


Related Products

Maleimide Assay Kit (Cat. CM90002): The average maleimide groups per antibody is 4 after SMCC labeling. If necessary, you can purchase this kit separately from CellMosaic to assay the maleimide content. The kit is simple and easy to use. Approximate total assay time is 1 h.

PerKit™ Fab Preparation Kit (Cat. CM51407)

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