Ang 1-7 is a biologically active peptide of the renin-angiotensin system. Ang I-7 binds the Mas receptor, which mediates vasodilation and the antiproliferative actions of the heptapeptide. Endogenous Ang 1-7 is generated by angiotensin-converting enzyme 2 (ACE 2) mediated degradation of Ang II. It can also be formed from Ang I or Ang II by other peptidases.

Chemical Information

• Chemical name: angiotensin 1-7
• Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro (or DRVYIHP)
• C-terminus: free acid;                      N-terminus: free amine
• Counter ion: trifluoroactate salt;       Chemical formula: C₄₁H₆₂N₁₂O₁₁
• Molecular weight: 899.01;               CAS number: 51833-78-4

Specification

• Physical appearance: lyophilized powder;         Storage temp.: -20 °C
• Purity: ≥ 95 % by HPLC 

References

Recent reviews for Ang 1-7:

1. Iusuf D, Henning RH, van Gilst WH, Roks AJ. Eur J Pharmacol. 2008 May 13;585(2-3):303-12. Epub 2008 Mar 15; 2. Santos RA, Ferreira AJ. Curr Opin Nephrol Hypertens. 2007 Mar;16(2):122-8; 3. Santos RA, Frézard F, Ferreira AJ. Curr Med Chem Cardiovasc Hematol Agents. 2005 Oct;3(4):383-91.

Selected papers:

1. Chappell, M.C., Brosnihan, K.B., Diz, D.I. and Ferrario, C.M. J. Biol. Chem., 1989, 264, 16518-16523; 2. Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM. Proc Natl Acad Sci USA 1988; 85: 4095–8; 3. Ferrario CM. Hypertension 2006; 47: 515–21; 4. Watanabe T, Barker TA, Berk BC. Hypertension 2005; 45: 163–9; 5. Santos RA, Castro CH, Gava E et al. Hypertension 2006; 47: 996–1002.